The Earthrealm heroes must journey to the Outworld and fight for the survival of their homeland, invaded by the forces of evil warlord Shao Kahn, in the tournament to end all tournaments: the final Mortal Kombat.

In the near future, nanotechnology administered into the bloodstream can sync with computer apps to augment the human genome. A new law mandating and regulating this once elective procedure meets resistance from hacktivists who are conspiring to thwart the impending roll-out of "Nano version 2.0."